Biólogo y Magister en Ciencias mención Genética de la Universidad Austral de Chile, Dr. En Ciencias Biomédicas, Universidad de Chile, Facultad de Medicina. Profesor Asociado del Departamento de Producción Animal de la Facultad de Ciencias Agronómicas. Actualmente es el profesor responsable del curso de Genética y Bases del Mejoramiento para los estudiantes de Ingeniería Agronómica, y de los cursos de Estadística Experimental para estudiantes de Magister en Ciencias de la Acuicultura y de Bioestadística I para estudiantes de Magister en Genética. Pertenece a los claustros académicos de los Doctorados en Ciencias Silvoagropecuarias y Veterinarias, y Doctorado en Acuicultura de nuestra Universidad. Además, es miembro de los claustros del Magíster en Ciencias Agropecuarias y Magister en Ciencias de la Acuicultura de la Facultad de Ciencias Agronómicas, Magister en Genética de la Facultad de Medicina y Magister en Alimentos mención Gestión, Calidad e Inocuidad de los Alimentos de la Facultad de Ciencias Químicas y Farmacéuticas. También participa del Food Quality Research Centre, unidad de investigación inter-facultades de la Universidad de Chile con vinculación internacional. Su investigación se ha enfocado en dos áreas principales: a) desarrollar herramientas genéticas/genómicas para apoyar la producción de alimentos marinos (peces y moluscos) en temas de calidad y trazabilidad molecular; b) Identificar y caracterizar regiones genómicas asociadas con rasgos productivos en especies en acuícolas (peces y moluscos) aplicables al mejoramiento genético. Los principales modelos biológicos utilizados en estas áreas han sido los mejillones, salmónidos y el pez cebra.

Biologist and Master of Science in Genetics from the Austral University of Chile, Dr. In Biomedical Sciences from the University of Chile, Faculty of Medicine. Up today he is an Associate Professor of the Department of Animal Production of the Faculty of Agricultural Sciences and is part of the Food Quality Research Laboratory, an inter-faculty research unit of the University of Chile with international links. He is currently the professor in charge of the Genetics and Basis of Improvement course for the students of Agronomic Engineering, and the courses of Experimental Statistics for students of Magister in Sciences of the Aquaculture and Biostatistics I for students of Magister in Genetics.His research has focused on two main areas: a) development of genetic/genomic tools to support the production of seafood (fish and mollusks) on issues of quality and molecular traceability; b) Identification and characterization genomic regions associated with productive traits in aquaculture species (fish and mollusks) applicable to genetic improvement. The main biological models used in these areas have been marine mussels, salmonids and zebrafish.

Yael González Tinoco presenta:

Derntl, Christian, et al. "Transcription factor Xpp1 is a switch between primary and secondary fungal metabolism." Proceedings of the National Academy of Sciences 114.4 (2017): E560-E569.

https://www.pnas.org/content/114/4/E560.short

Abstract

Fungi can produce a wide range of chemical compounds via secondary metabolism. These compounds are of major interest because of their (potential) application in medicine and biotechnology and as a potential source for new therapeutic agents and drug leads. However, under laboratory conditions, most secondary metabolism genes remain silent. This circumstance is an obstacle for the production of known metabolites and the discovery of new secondary metabolites. In this study, we describe the dual role of the transcription factor Xylanase promoter binding protein 1 (Xpp1) in the regulation of both primary and secondary metabolism of Trichoderma reesei. Xpp1 was previously described as a repressor of xylanases. Here, we provide data from an RNA-sequencing analysis suggesting that Xpp1 is an activator of primary metabolism. This finding is supported by our results from a Biolog assay determining the carbon source assimilation behavior of an xpp1 deletion strain. Furthermore, the role of Xpp1 as a repressor of secondary metabolism is shown by gene expression analyses of polyketide synthases and the determination of the secondary metabolites of xpp1 deletion and overexpression strains using an untargeted metabolomics approach. The deletion of Xpp1 resulted in the enhanced secretion of secondary metabolites in terms of diversity and quantity. Homologs of Xpp1 are found among a broad range of fungi, including the biocontrol agent Trichoderma atroviride, the plant pathogens Fusarium graminearum and Colletotrichum graminicola, the model organism Neurospora crassa, the human pathogen Sporothrix schenckii, and the ergot fungus Claviceps purpurea.

José Luis Duarte de Jesús presenta:

Aguiar, Eric Roberto Guimaraes Rocha, et al. "Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host." Nucleic acids research 43.13 (2015): 6191-6206.

https://academic.oup.com/nar/article/43/13/6191/2414271

Abstract

Virus surveillance in vector insects is potentially of great benefit to public health. Large-scale sequencing of small and long RNAs has previously been used to detect viruses, but without any formal comparison of different strategies. Furthermore, the identification of viral sequences largely depends on similarity searches against reference databases. Here, we developed a sequence-independent strategy based on virus-derived small RNAs produced by the host response, such as the RNA interference pathway. In insects, we compared sequences of small and long RNAs, demonstrating that viral sequences are enriched in the small RNA fraction. We also noted that the small RNA size profile is a unique signature for each virus and can be used to identify novel viral sequences without known relatives in reference databases. Using this strategy, we characterized six novel viruses in the viromes of laboratory fruit flies and wild populations of two insect vectors: mosquitoes and sandflies. We also show that the small RNA profile could be used to infer viral tropism for ovaries among